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Biocapacitance Measurement: A PAT Tool for Biomass Measurement in an Upstream Process

Process analytical technologies (PAT) are a class of innovative technologies that align with the principles of quality by design (QbD) by bringing visibility to product quality attributes at the point of control. This is opposed to the traditional approach of post-batch laboratory testing of critical attributes. Biocapacitance technology is an online PAT tool for continuous monitoring of biomass in a mammalian or microbial bioprocess. In this paper, we show three applications of biocapacitance measurement technology.

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How biocapacitance is used to measure online biomass in mammalian cell processes.

How biocapacitance is used in a CHO continuous process.

The use of the biocapacitance probe to monitor biomass in an E. coli fermentation process.

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Catalent is the global leader in enabling pharma, biotech, and consumer health partners to optimize product development, launch, and full life-cycle supply for patients around the world. With broad and deep scale and expertise in development sciences, delivery technologies, and multi-modality manufacturing, Catalent is a preferred industry partner for personalized medicines, consumer health brand extensions, and blockbuster drugs. Catalent helps accelerate over 1,000 partner programs and launch over 150 new products every year. Its flexible manufacturing platforms at over 50 global sites supply over 70 billion doses of more than 7,000 products to over 1,000 customers annually. Catalent’s expert workforce exceeds 17,000, including more than 2,500 scientists and technicians. Headquartered in Somerset, New Jersey, the company generated $4 billion in revenue in its 2021 fiscal year. For more information, visit www.catalent.com.

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